Table 4 Interaction effects of animal iron and selected risk factors on the risk of NAFLD.

Exposures		Quartiles of animal iron intake				P-value for multiplicative interactions
Exposures		Q1	Q2	Q3	Q4	P-value for multiplicative interactions
Smoking ^b
No	Cases/controls a	193/250	211/232	196/240	263/242	0.119
No	OR (95%CI)	1.00	1.31 (0.97–1.78)	1.46 (1.04–2.05)	1.51 (1.06–2.15)
Yes	Cases/controls a	47/68	103/87	84/77	176/77
Yes	OR (95%CI)	0.85 (0.52–1.40)	1.45 (0.96–2.19)	1.73 (1.11–2.72)	3.35 (2.20–5.12)
Moderate alcohol drinker ^c
No	Cases/controls a	185/254	218/221	200/267	263/179	0.628
No	OR (95%CI)	1.00	1.43 (1.05–1.94)	1.38 (0.99–1.933)	2.14 (1.49–3.08)
Yes	Cases/controls a	55/64	96/98	80/50	176/140
Yes	OR (95%CI)	1.04 (0.65–1.67)	1.36 (0.91–2.02)	2.43 (1.52–3.89)	1.76 (1.19–2.59)
Dietary fat intake ^d
Low	Cases/controls a	234/315	251/265	70/68	17/14	0.041
Low	OR (95%CI)	1.00	1.35 (1.02–1.78)	1.82 (1.18–2.80)	1.78 (0.75–4.22)
High	Cases/controls a	6/3	63/54	210/249	422/305
High	OR (95%CI)	4.48 (0.74–27.14)	1.82 (1.14–2.91	1.56 (1.12–2.17)	2.08 (1.50–2.89)
Overweight or obesity ^e
No	Cases/controls a	135/275	167/283	173/298	132/259	0.006
No	OR (95%CI)	1.00	1.33 (0.96–1.82)	1.74 (1.23–2.47)	1.31 (0.89–1.94)
Yes	Cases/controls	105/42	147/36	104/19	307/60
Yes	OR (95%CI)	4.31 (2.75–6.76)	7.53 (4.74–11.96)	10.35 (5.77–18.56)	9.15 (5.96–14.07)

^aThe number of cases/controls in each cell is followed by the odds ratio (OR) and 95% confidence interval (95% CI) for NAFLD.
^bORs and P-values for multiplicative interactions are adjusted for age, gender, family income, education, moderate alcohol consumption, BMI, regular exercise, total energy intake, total fat intake, systolic blood pressure, and biochemistry.
^cORs and P-values for multiplicative interactions are adjusted for age, gender, family income, education, smoking, BMI, regular exercise, total energy intake, total fat intake, systolic blood pressures, and biochemistry.,
^dORs and P-values for multiplicative interactions are adjusted for age, gender, family income, education, smoking, moderate alcohol consumption, BMI, regular exercise, total energy intake, systolic blood pressure, and biochemistry.
^eORs and P-values for multiplicative interactions are adjusted for age, gender, family income, education, smoking, moderate alcohol consumption, regular exercise, total energy intake, total fat intake, systolic blood pressure, and biochemistry.

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