Figure 2
From: Characterization of polydactyly chondrocytes and their use in cartilage engineering
Schematic of the study. Cartilage was harvested from joints of children undergoing surgical correction of polydactyly (a) and cells were isolated from the tissue (b). Polydactyly chondrocytes were characterized for their de-differentiation profile and for their and re-differentiation ability in 2D and in 3D. 3D studies (c) included centrifuged pellet culture and encapsulation in a hyaluronic acid-derived hydrogel, HA-TG. For further in vivo studies, the cells were encapsulated in a mix of HA-TG and modified heparin (heparin-TG) in a cartilage explant model for delivery of TGF-β1.
