Table 1 Number of significantly regulated peptides and proteins based on a +/− 30% fold-change and p ≤ 0.05 comparing all disease phenotypes.

From: Combined Tissue-Fluid Proteomics to Unravel Phenotypic Variability in Amyotrophic Lateral Sclerosis

 

Differentially-expressed peptides

Differentially-expressed proteins

PBMC study

B-ALS vs L-ALS

1,003

132

B-ALS fast vs B-ALS slow

230

28

L-ALS fast vs L-ALS slow

185

20

B-ALS fast vs L-ALS fast

1,039

150

B-ALS slow vs L-ALS slow

502

88

Plasma/brain study

B-ALS vs L-ALS

2,759

554

  1. In the PBMC study, the comparison B-ALS versus L-ALS within the group of fast progressing patients showed the highest number of significantly regulated proteins and peptides. For this reason, for the plasma/brain proteomic study, bulbar and limb onset patients with a more rapid disease progression were selected.