Table 3 Top20 regulated pathways mapped by regulated peptides identified in plasma/brain proteomes comparing B-ALS versus L-ALS (peptide level). Terms are sorted by adjusted p-values.
From: Combined Tissue-Fluid Proteomics to Unravel Phenotypic Variability in Amyotrophic Lateral Sclerosis
Plasma_Top20 regulated Pathways | Effect size | adj.pvalue |
|---|---|---|
Initial triggering of complement | −0.45 | 1.1E-03 |
Muscle contraction [Reactome] | 0.65 | 1.3E-03 |
Regulation of Complement cascade | −0.44 | 1.3E-03 |
FCGR activation | −0.52 | 1.3E-03 |
Rap1 signaling pathway | 0.44 | 2.7E-03 |
Smooth Muscle Contraction | 0.82 | 2.8E-03 |
Leukocyte transendothelial migration | 0.56 | 3.0E-03 |
Glycosaminoglycan metabolism [Reactome] | −0.83 | 3.4E-03 |
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | −0.41 | 4.9E-03 |
Focal adhesion | 0.48 | 5.1E-03 |
Inflammatory Response Pathway | −0.78 | 6.4E-03 |
Role of phospholipids in phagocytosis | −0.46 | 6.7E-03 |
RHO GTPases Activate ROCKs | 0.87 | 7.3E-03 |
S1P4 pathway | 0.66 | 7.5E-03 |
Sema4D in semaphorin signaling | 0.74 | 8.2E-03 |
Sema4D induced cell migration and growth-cone collapse | 0.74 | 8.2E-03 |
Isobutyryl-coa dehydrogenase deficiency | −0.71 | 8.2E-03 |
Isovaleric acidemia | −0.71 | 8.2E-03 |
Isovaleric Aciduria | −0.71 | 8.2E-03 |
Maple Syrup Urine Disease | −0.71 | 8.2E-03 |
