Table 4 Significantly regulated pathways (p-value < 0.05) shared between the two studies.
From: Combined Tissue-Fluid Proteomics to Unravel Phenotypic Variability in Amyotrophic Lateral Sclerosis
Regulated pathways found in PBMCs and plasma proteomes | Matched proteins in PBMCs | Matched proteins in Plasma |
|---|---|---|
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | Immunoglobulin kappa constant, HLA class I histocompatibility antigen, A-2 alpha chain, Integrin beta-1 | Tetraspanin, Complement C3, Immunoglobulin kappa variable 1–39, Immunoglobulin kappa variable 1–5, Immunoglobulin kappa variable 3–20, Immunoglobulin kappa variable 4–1, Immunoglobulin lambda variable 1–47, Immunoglobulin lambda variable 3–19, Immunoglobulin lambda variable 3–25, Immunoglobulin heavy variable 1–69, Immunoglobulin heavy variable 3–11, Immunoglobulin heavy variable 3–23, Immunoglobulin heavy variable 3–23, Immunoglobulin heavy variable 3–7, Immunoglobulin heavy variable 4–39, Immunoglobulin heavy variable 4–39, Collagen alpha-1(I) chain, Immunoglobulin kappa variable 3–15, Immunoglobulin lambda variable 1–47, Beta-2-microglobulin, Immunoglobulin lambda variable 3–21, Intercellular adhesion molecule 5 |
Regulation of actin cytoskeleton | Actin-related protein 2/3 complex subunit 1B, Actin-related protein 2/3 complex subunit 2, Actin-related protein 2/3 complex subunit 5, Alpha-actinin-4, Integrin beta-3, Integrin beta-1, Profilin-1, Integrin alpha-M, Ras-related C3 botulinum toxin substrate 2, Ezrin | Cytoplasmic FMR1-interacting protein 2, Actin-related protein 2/3 complex subunit 2, Actin-related protein 2/3 complex subunit 3, Alpha-actinin-4, Prothrombin, Gelsolin, Profilin-1, Proto-oncogene tyrosine-protein kinase Src, Myosin regulatory light chain 12A, Moesin, Mitogen-activated protein kinase 3, Mitogen-activated protein kinase 1, Radixin, Myosin-9, Alpha-actinin-2, Dual specificity mitogen-activated protein kinase kinase 2, Actin, cytoplasmic 1, Cell division control protein 42 homolog, Transforming protein RhoA, Serine/threonine-protein phosphatase PP1-alpha catalytic subunit, Serine/threonine-protein phosphatase PP1-beta catalytic subunit, Thymosin beta-4, Ras-related C3 botulinum toxin substrate 1, Phosphatidylinositol 5-phosphate 4-kinase type-2 beta, Serine/threonine-protein kinase PAK 1, Myosin-14, Actin-related protein 2/3 complex subunit 5-like protein, Nck-associated protein 1 |
RHO GTPases activate CIT | Myosin-9, Transforming protein RhoA | Myosin-9, Transforming protein RhoA, Rho-related GTP-binding protein RhoB, Myosin-14, Ras-related C3 botulinum toxin substrate 1 |
RHO GTPases activate PAKs | Myosin-9, Cell division control protein 42 homolog, Calmodulin-1, Calmodulin-2, Calmodulin-3, Serine/threonine-protein kinase PAK 2 | Myosin-9, Cell division control protein 42 homolog, Serine/threonine-protein phosphatase PP1-beta catalytic subunit, Ras-related C3 botulinum toxin substrate 1, Serine/threonine-protein kinase PAK 1, Filamin-A, Myosin-14 |
RHO GTPases Activate ROCKs | Myosin-9, Transforming protein RhoA | Myosin-9, Transforming protein RhoA, Myosin-14, Serine/threonine-protein phosphatase PP1-beta catalytic subunit, Rho-related GTP-binding protein RhoB |
Salmonella infection | Actin-related protein 2/3 complex subunit 1B, Actin-related protein 2/3 complex subunit 2, Actin-related protein 2/3 complex subunit 5, Profilin-1, Myosin-9, Actin-related protein 2/3 complex subunit 4, Actin, cytoplasmic 1, Cell division control protein 42 homolog, Rho-related GTP-binding protein RhoG | Actin-related protein 2/3 complex subunit 2, Actin-related protein 2/3 complex subunit 3, Profilin-1, Mitogen-activated protein kinase 3, Mitogen-activated protein kinase 1, Myosin-9, Ras-related protein Rab-7a, Actin, cytoplasmic 1, Cell division control protein 42 homolog, Ras-related C3 botulinum toxin substrate 1, Rho-related GTP-binding protein RhoG, Tight junction protein ZO-1, Cytoplasmic dynein 1 heavy chain 1, Fatty acid-binding protein, liver, Myosin-14, Actin-related protein 2/3 complex subunit 5-like protein |
Sema4D in semaphorin signaling | Myosin-9, Transforming protein RhoA, Ras-related C3 botulinum toxin substrate 2, Cell division control protein 42 homolog, Rho-related GTP-binding protein RhoG | Myosin-9, Cell division control protein 42 homolog, Transforming protein RhoA, Rho-related GTP-binding protein RhoB, Ras-related C3 botulinum toxin substrate 1, Rho-related GTP-binding protein RhoG, Myosin-14 |
Sema4D induced cell migration and growth-cone collapse | Myosin-9, Transforming protein RhoA, Ras-related C3 botulinum toxin substrate 2, Cell division control protein 42 homolog, Rho-related GTP-binding protein RhoG | Myosin-9, Cell division control protein 42 homolog, Transforming protein RhoA, Rho-related GTP-binding protein RhoB, Ras-related C3 botulinum toxin substrate 1, Rho-related GTP-binding protein RhoG, Myosin-14 |
Semaphorin interactions | Integrin beta-1, Heat shock protein HSP 90-alpha, Heat shock protein HSP 90-beta, Ras-related C3 botulinum toxin substrate 2, Cofilin-1, Myosin-9, Cell division control protein 42 homolog, Transforming protein RhoA, Rho-related GTP-binding protein RhoG, Serine/threonine-protein kinase PAK 2, Talin-1 | Dihydropyrimidinase-related protein 4, Heat shock protein HSP 90-alpha, Heat shock protein HSP 90-beta, Myosin-9, Cell division control protein 42 homolog, Transforming protein RhoA, Rho-related GTP-binding protein RhoB, Ras-related C3 botulinum toxin substrate 1, Rho-related GTP-binding protein RhoG, Cyclin-dependent-like kinase 5, Serine/threonine-protein kinase PAK 1, Dihydropyrimidinase-related protein 1, Dihydropyrimidinase-related protein 2, Myosin-14, Dihydropyrimidinase-related protein 5, Talin-1 |
