Figure 13

Outcome of the simulated model Model 4 with PRISM. Only 80 of the 92 kinetochores could be realized. The x-axis presents the transition probability with which state ‘attached’ goes to ‘about to exit’ and the y-axis the probability of a successful SAC. Left: This example shows lined up kinetochores, meaning 2 neighbors for each kinetochore. Middle: A more connected graph with five neighbors per kinetochore. Right: An even more connected graph with 7 neighbors per kinetochore. This shows that the success depends slightly on the aforementioned probability but considerably more on the neighborhood range. Clearly a graph that is not fully connected results in a checkpoint defect.