Table 2 Physiological parameters at baseline, 0 h (end of insult), 1 h, 6 h, 12 h, and 24 h after the insult.

From: Hydrogen ventilation combined with mild hypothermia improves short-term neurological outcomes in a 5-day neonatal hypoxia-ischaemia piglet model

Parameters

 

Baseline

0 h

1 h

6 h

12 h

24 h

HR (bpm)

NT

211.6 ± 29.9

146.8 ± 19.4****

233.3 ± 24.8

238.8 ± 14.5#

237.6 ± 22.5#

203.3 ± 30.9

TH

214.8 ± 42.0

172.8 ± 42.0*

202.4 ± 36.8

213.9 ± 7.4#

210.4 ± 14.0#

185.4 ± 4.2

TH-H2

215.2 ± 10.9

160.2 ± 21.8**

234.3 ± 24.9

182.2 ± 21.9

176.8 ± 30.1

177.0 ± 23.2

MABP (mmHg)

NT

79.0 ± 7.0

47.3 ± 13.3****

62.6 ± 7.0**

70.0 ± 11.9

69.8 ± 8.3

62.1 ± 8.9**

TH

79.5 ± 16.1

51.3 ± 10.9****

74.9 ± 6.3

70.3 ± 8.3

69.3 ± 8.3

63.0 ± 8.5*

TH-H2

73.2 ± 9.6

49.3 ± 14.0***

68.0 ± 2.9

74.7 ± 8.3

68.7 ± 8.8

65.0 ± 4.4

RT (°C)

NT

37.7 ± 0.7

37.7 ± 0.6

38.2 ± 0.6#

38.5 ± 0.3*,#

37.9 ± 0.5#

38.4 ± 0.5#

TH

36.8 ± 0.7

36.8 ± 0.8

33.7 ± 0.8****,#

33.9 ± 0.3****

34.0 ± 0.4****,#

34.2 ± 0.4****

TH-H2

38.2 ± 0.8

37.5 ± 0.9

36.4 ± 1.1

32.8 ± 1.3****

32.9 ± 0.9****

35.2 ± 1.6**

  1. Values are expressed as mean ± SD. NT indicates normothermia; RT, rectal temperature; TH, therapeutic hypothermia and TH-H2, therapeutic hypothermia with hydrogen ventilation. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 versus baseline; #p < 0.05 versus TH-H2.
Back to article page