Table 3 Arterial blood gas data at baseline and 0 h (end of insult), 1 h, 6 h, 12 h, and 24 h after the insult.

From: Hydrogen ventilation combined with mild hypothermia improves short-term neurological outcomes in a 5-day neonatal hypoxia-ischaemia piglet model

Parameters

 

Baseline

0 h

1 h

6 h

12 h

24 h

pH

NT

7.42 ± 0.05

6.85 ± 0.09****

7.30 ± 0.06**

7.46 ± 0.04

7.46 ± 0.05#

7.50 ± 0.05*,#

TH

7.44 ± 0.11

6.79 ± 0.09****

7.22 ± 0.10****,#

7.45 ± 0.05

7.44 ± 0.05#

7.43 ± 0.04#

TH-H2

7.43 ± 0.03

6.90 ± 0.09****

7.36 ± 0.08

7.40 ± 0.04

7.37 ± 0.04

7.35 ± 0.05

pCO2 (mmHg)

NT

46.9 ± 4.6

34.5 ± 10.6**

42.2 ± 6.2

47.5 ± 5.9

45.1 ± 4.6

39.3 ± 3.1

TH

41.6 ± 11.8

44.8 ± 12.8

43.8 ± 8.7

41.9 ± 7.0

40.9 ± 6.7

36.4 ± 5.3

TH-H2

43.0 ± 3.4

39.2 ± 11.6

37.8 ± 3.4

43.7 ± 4.7

43.8 ± 2.0

42.4 ± 6.6

pO2 (mmHg)

NT

89.6 ± 10.8

17.5 ± 6.7****

94.5 ± 26.5

89.3 ± 9.4

85.8 ± 14.2

89.7 ± 14.1

TH

98.3 ± 13.7

19.7 ± 6.3****

115.4 ± 22.3

82.8 ± 22.1

83.7 ± 23.2

81.4 ± 20.5

TH-H2

104.5 ± 4.4

26.2 ± 18.1****

121.7 ± 23.1

105.0 ± 18.7

103.5 ± 17.7

109.8 ± 29.0

BE (mmol/L)

NT

5.8 ± 2.3

−26.0 ± 4.7****

–5.5 ± 3.7****

8.6 ± 1.5#

7.2 ± 3.2#

6.8 ± 2.5#

TH

3.1 ± 3.0

−27.3 ± 31****

–9.8 ± 4.3****

4.5 ± 2.9

3.5 ± 3.0

0.0 ± 2.7

TH-H2

3.6 ± 2.0

−22.5 ± 3.2****

–3.8 ± 4.2**

2.2 ± 3.6

0.7 ± 2.8

–2.1 ± 3.8*

Lactate (mg/dL)

NT

18.0 ± 4.1

227.1 ± 26.2****,#

122.5 ± 28.4****

27.8 ± 9.2

36.9 ± 11.0

34.4 ± 9.7

TH

20.0 ± 8.3

213.5 ± 23.7****,#

121.9 ± 26.3****

33.3 ± 14.4

39.4 ± 14.4

49.5 ± 11.4*

TH-H2

16.8 ± 2.2

172.8 ± 22.8****

91.5 ± 17.8****

32.7 ± 6.2

38.8 ± 5.9

56.7 ± 24.0**

Glucose (mg/dL)

NT

146.0 ± 18.1

253.5 ± 68.5**

237.0 ± 53.3*

183.9 ± 53.1

195.5 ± 67.9

115.6 ± 37.5

TH

155.8 ± 37.6

230.8 ± 97.7

256.5 ± 65.5*

219.4 ± 66.9

222.1 ± 68.7

191.0 ± 48.3

TH-H2

147.5 ± 18.8

231.3 ± 62.1*

204.0 ± 51.0

194.7 ± 40.8

230.0 ± 22.5*

179.2 ± 67.9

  1. Values are expressed as mean ± SD. NT indicates normothermia; TH, therapeutic hypothermia and TH-H2, therapeutic hypothermia with hydrogen ventilation. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 versus baseline; #p < 0.05 versus TH-H2.