Table 2 Hazard ratios (with 95% CIs) for variables evaluated as potential predictors of all-cause mortality in the study population.
From: Predictors of outcomes in patients on peritoneal dialysis: A 2-year nationwide cohort study
Factors | n (%) | Unadjusted | Adjusted | ||||
|---|---|---|---|---|---|---|---|
HR | 95% CI | P-value | HR | 95% CI | P-value | ||
Sex | |||||||
Male | 5,714 (63.8) | 1.000 | Reference | Reference | 1.000 | Reference | Reference |
Female | 3,240 (36.2) | 0.898 | 0.787–1.025 | 0.114 | 0.772 | 0.438–1.378 | 0.376 |
Age | |||||||
1-year increase | 8,954 (100) | 1.081 | 1.073–1.087 | <0.0001 | 1.113 | 1.078–1.149 | <0.0001 |
PD duration (years) | |||||||
<2 | 3,507 (39.2) | 1.000 | Reference | Reference | 1.000 | Reference | Reference |
≥2 <4 | 2,344 (26.2) | 1.170 | 0.978–1.399 | 0.086 | 1.374 | 0.966–1.953 | 0.076 |
≥4 <6 | 1,422 (15.9) | 1.432 | 1.165–1.762 | 0.001 | 1.627 | 1.173–2.256 | 0.004 |
≥6 <8 | 761 (8.5) | 1.676 | 1.233–2.278 | 0.001 | 1.720 | 1.041–2.841 | 0.045 |
≥8 <10 | 414 (4.6) | 1.545 | 1.093–2.183 | 0.013 | 2.211 | 1.377–3.549 | 0.002 |
≥10 | 506 (5.6) | 1.506 | 1.113–2.036 | 0.007 | 2.979 | 1.687–5.259 | 0.002 |
Diabetes | |||||||
No | 5,635 (62.9) | 1.000 | Reference | Reference | 1.000 | Reference | Reference |
Yes | 3,319 (37.1) | 1.500 | 1.318–1.708 | <0.0001 | 1.648 | 1.097–2.474 | 0.016 |
Comorbid CVD | |||||||
No | 7,399 (84.9) | 1.000 | Reference | Reference | 1.000 | Reference | Reference |
Yes | 1,313 (15.1) | 2.861 | 2.464–3.322 | <0.0001 | 1.367 | 1.055–1.771 | 0.017 |
Use of antihypertensive medication | |||||||
No | 1,264 (20.8) | 1.000 | Reference | Reference | 1.000 | Reference | Reference |
Yes | 4,802 (79.2) | 0.509 | 0.422–0.615 | <0.0001 | 0.667 | 0.501–0.889 | 0.005 |
Residual renal function | |||||||
Non-anuric | 3,479 (77.2) | 1.000 | Reference | Reference | 1.000 | Reference | Reference |
Anuric | 1,026 (22.8) | 1.677 | 1.330–2.114 | <0.0001 | 1.257 | 0.785–1.984 | 0.335 |
Total Kt/V | |||||||
<1.1 | 286 (8.7) | 2.313 | 1.481–3.614 | 0.001 | 2.431 | 0.925–6.386 | 0.071 |
≥1.1 <1.4 | 326 (9.9) | 1.392 | 0.806–2.405 | 0.235 | 1.162 | 0.419–3.222 | 0.772 |
≥1.4 <1.7 | 682 (20.7) | 1.000 | Reference | Reference | 1.000 | Reference | Reference |
≥1.7 <2.0 | 853 (25.9) | 1.159 | 0.784–1.713 | 0.457 | 0.792 | 0.350–1.791 | 0.576 |
≥2.0 | 1,144 (34.8) | 0.832 | 0.563–1.230 | 0.358 | 0.614 | 0.262–1.437 | 0.262 |
Use of 2.5% dialysate | |||||||
No | 3,422 (62.5) | 1.000 | Reference | Reference | 1.000 | Reference | Reference |
Yes | 2,056 (37.5) | 1.502 | 1.267–1.779 | <0.0001 | 2.551 | 1.433–4.539 | 0.001 |
Use of icodextrin dialysate | |||||||
No | 3,241 (59.2) | 1.000 | Reference | Reference | 1.000 | Reference | Reference |
Yes | 2,237 (40.8) | 1.307 | 1.102–1.548 | 0.002 | 0.968 | 0.641–1.445 | 0.876 |
PD + HD combination therapy | |||||||
No | 7,275 (81.2) | 1.000 | Reference | Reference | 1.000 | Reference | Reference |
Yes | 1,679 (18.8) | 0.556 | 0.438–0.703 | <0.0001 | 0.595 | 0.413–0.858 | 0.005 |
Hemoglobin | |||||||
1-g/dL increase | 6,130 (68.5) | 0.773 | 0.726–0.823 | <0.0001 | 0.925 | 0.844–1.014 | 0.098 |
C-reactive protein | |||||||
1-mg/dL increase | 5,344 (59.7) | 1.571 | 1.467–1.682 | <0.0001 | 1.217 | 1.073–1.381 | 0.002 |
Body mass index | |||||||
1-kg/m2 increase | 5,330 (59.5) | 0.910 | 0.885–0.935 | <0.0001 | 0.906 | 0.847–0.969 | 0.004 |
Serum albumin | |||||||
1-g/dL increase | 6,092 (68.0) | 0.217 | 0.190–0.247 | <0.0001 | 0.363 | 0.234–0.562 | <0.0001 |
Non-HDL cholesterol | |||||||
1-mg/dL increase | 3,658 (40.9) | 0.996 | 0.993–0.999 | 0.042 | 0.995 | 0.989–1.001 | 0.097 |
HDL cholesterol | |||||||
1-mg/dL increase | 4,264 (47.6) | 0.982 | 0.976–0.989 | <0.0001 | 0.981 | 0.968–0.995 | 0.008 |
Calcium (mg/dL) | |||||||
1-mg/dL increase | 6,175 (69.0) | 0.748 | 0.685–0.819 | <0.0001 | 1.145 | 0.877–1.493 | 0.317 |
Phosphate (mg/dL) | |||||||
1-mg/dL increase | 7,340 (82.0) | 0.871 | 0.818–0.925 | <0.0001 | 1.231 | 1.046–1.450 | 0.012 |
