Figure 2 | Scientific Reports

Figure 2

From: Integrated analysis of relapsed B-cell precursor Acute Lymphoblastic Leukemia identifies subtype-specific cytokine and metabolic signatures

Figure 2

Relapse-specific alteration events of the BCP-ALL patients reveal enrichment of metabolism and chromatin modifier genes. (a) Shows relapse-specific mutations and copy number losses. Genes, which had at least one relapse-specific mutation, were selected for their implication in cancer or resistance mechanism. Genes (n = 21) have been classified into three the categories: metabolism, chromatin modifier and TP53 + others. The plot shows that 40 out of 50 (80%) patients have at least one relapse-specific alteration. (b) The relapse-specific missense mutation metabolism-related genes FPGS and AGBL1 are shown in the amino acid sequence. Domains have been obtained from InterPro.

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