Figure 3 | Scientific Reports

Figure 3

From: Integrated analysis of relapsed B-cell precursor Acute Lymphoblastic Leukemia identifies subtype-specific cytokine and metabolic signatures

Figure 3

DUX4 relapse-specific gene expression, regulation and pathway analyses reveal a chemokine-driven gene signature. (a) Shows the genes involved in the pathways and GO-terms enriched in REL compared to ID (n = 11; ID n = 12) of the DUX4 subtype that are annotated to an enriched pathway in subfigure (b). The heatmap is clustered by columns and rows (euclidean median hierarchical clustering), represented by the color-coded bars on the left. The expression data show gene-centered fold changes of log2 TPM. (b) Relapse-specific expression signature pathways in the DUX4 subtype. Pathways of interest have been labeled and the edges between the nodes that represent pathways and GO-terms indicate that they share common genes. The FIPlugin for Cytoscape has been used to cluster the network. The resulting clusters are designated by node colors and with labels ranging from M0 to M6. (c) GSEA plots for Reactome pathways IL-10 Signaling and Chemokine Receptors. The strong up-regulation of both of these and other pathways corroborate the results in (a,b).

Back to article page