Table 1 Molecular events biased towards subgroups. Samples from early relapse (ER; time of REL <700 days) showed a bias towards deletions involving the CDKN2A/B locus as 13 of the 15 deletions were associated with an early relapse as well as mutations or copy number losses of PTPRD (7/7).
Gene | Early Relapse (ER) Patients (n = 25) | Late Relapse (LR) Patients (n = 25) | p-value |
|---|---|---|---|
CDKN2B | 13 deletions | 2 deletions | <0.01 |
CDKN2A | 13 deletions | 3 deletions | <0.01 |
PTPRD | 7 (6 deletions/1 mutation) | 0 alterations | <0.01 |
PRSS3 | 8 (7 deletions/1 mutation) | 1 deletion | 0.02 |
IKZF1 | 2 (1 deletion/1 mutation) | 9 (4 mutations/3 deletions/2 double hits) | 0.04 |
Pediatric Patients (n = 26) | Adult Patients (n = 24) | ||
NR3C1 | 7 (6 deletions/1 mutation) | 0 alterations | 0.01 |
CREBBP | 1 deletion | 7 (5 mutations/2 deletions) | 0.02 |
KMT2D | 1 mutation | 6 mutations | 0.05 |
EZH2 | 0 alterations | 4 (2 mutations/2 deletions) | 0.05 |
TP53 | 3 (2 double hits/1 mutation) | 8 (3 double hits/3 mutations/2 deletions) | 0.09 |
NT5C2 | 4 mutations | 0 alterations | 0.11 |
