Figure 7 | Scientific Reports

Figure 7

From: The Parkinson’s disease-linked Leucine-rich repeat kinase 2 (LRRK2) is required for insulin-stimulated translocation of GLUT4

Figure 7

The role of LRRK2 for insulin signal transduction. (a) In wild-type, GDP-bound Rab10 is tightly bound by guanine dissociation inhibitor (GDI) in the cytosol. LRRK2 promotes the insertion of Rab10 in GLUT4 storage vesicles by phosphorylation. Insulin addition activates an insulin-dependent Phosphatase X with following dephosphorylation of Rab10 (accompanied by GDP-GTP exchange), necessary for efficient GLUT4 translocation. (b) In LRRK2 deficient situation, the phosphorylation of Rab10 by LRRK2 and the following insertion in GLUT4 storage vesicles fail. As consequence, GDP-bound Rab10 – GDI complexes accumulate in the cytosol. By insulin addition activated PI3K/Akt/AS160 signalling cascade did not reach the GLUT4 storage vesicles and the GLUT4 translocation fails.

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