Figure 3 | Scientific Reports

Figure 3

From: Analysis of repetitive element expression in the blood and skin of patients with Parkinson’s disease identifies differential expression of satellite elements

Figure 3

Upregulation of Satellite elements in the blood of PD patients. At the subfamily level four satellite class repetitive elements were significantly differentially expressed at FDR ≤ 0.01, two simple satellite III (repName = CATTC_n and _GAATG_n) a high-copy satellite II (repName = HSATII) and a centromeric satellite (repName = ALR_Alpha) all of which were upregulated in the blood of PD patients. Simple satellite III repeat (CATTC)n RNAs were the most significantly upregulated in the blood of PD patients (p-value = 2.27E-12) with a logFC increase of 4.40. Pericentromeric human satellite II (HSATII) repeat derived RNAs were significantly upregulated (p-value = 2.79E-12) with a logFC increase of 4.12. Simple satellite III (GAATG)n derived RNAs were upregulated in PD (p-value = 1.68E-11) with a logFC increase of 4.23. Finally, human alpha centromeric satellite (ALR_Alpha) derived RNAs were also upregulated in PD (p-value = 5.20E-08) with a 2.02 logFC increase.

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