Figure 2 | Scientific Reports

Figure 2

From: Loss of Neogenin1 in human colorectal carcinoma cells causes a partial EMT and wound-healing response

Figure 2

Whole transcriptome analysis of Caco-2 cells after Neo1 knockdown. (a) Principal component analysis (PCA) plot of Control and Neo1-siRNA treated cells showed 37% of variance in the first axis. (b) GO-term enrichment analysis of PCA loadings for each gene show the majority of the variance is associated with down-regulation of the oxidative phosphorylation pathway. (c) K-means clustering of the top 2000 variable genes clearly resolved in two clusters of genes up or down-regulated. (d) MA-plot of the 419 up-regulated and 170 down-regulated genes, significantly altered by Neo1 knockdown. (e) GO-term enrichment analysis of differentially expressed genes categorized into down-regulated and up-regulated pathways.

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