Figure 3
From: Post-transcriptional regulatory patterns revealed by protein-RNA interactions
RBPs belonging to the three sets have distinct features. (A) Enrichments (circles filled in green) and depletions (circles filled in violet) of different types of RNA-binding proteins among the three groups of RBPs were assessed using the Fisher’s Exact test. Size of the circles is proportional to the fraction of RBPs of a given type that are present in each of the RBP groups, and their frequency is reported as a number within the circle. Significant enrichments and depletions are denoted by one (P-value < 0.05) or two (P-value < 0.01) asterisks. E-RBP: RBPs showing only enrichments in targets among functional units; M-RBP set: RBPs displaying both significant enrichments and depletions of targets among functional units; D-RBP: RBPs display only significant depletions within functional units. (B) Distribution of the overall post-translational modification (PTM) density in the sequences of the three RBP groups. Densities for every RBP are computed as the number of experimentally identified PTM sites divided by the RBP sequence length. Black diamonds represent density mean values. Boxplot colors correspond to the RBP group colors in Fig. 2.
