Figure 4
From: The DNA damage induced by the Cytosine Deaminase APOBEC3A Leads to the production of ROS
The A3A-mediated production of ROS occurs via Nox enzymes. (A,B) Cycling U937 were induced with doxycycline in the presence of the Nox inhibitor DPI provided at a concentration of 0,5 μM. ROS production was then measured 48 hours after the initial induction of A3A. A typical result is presented in the histogram of (A), while the quantification of the percentage of ROS-positive cells (Averages and SEM) obtained in four independent experiments is displayed in (B).
