Table 1 List of the peptide analogs of HAI of and their residue substitutions. D-amino acids are shown in lowercase letters.
Peptide | Sequence | Substitution (“x”) |
|---|---|---|
1 L (HAI) | Ac-HAIYPRH-NH2 | — |
2 L | Ac-HAxYPRH-NH2 | homocyclohexyl-L-alanine |
3 L | Ac-HAIxPRH-NH2 | 7-hydroxy-(S)-1.2.3.4-tetrahydroisoquinoline-3-carboxylic acid |
4 L | Ac-HAIxPRH-NH2 | 4-amino-L-phenylalanine |
5 L | Ac-HAIxPRH-NH2 | 4-fluoro-L-phenylalanine |
6D (rD-HAI) | Ac-hrpyiah-NH2 | — |
7 + D | Ac-hrxyiah-NH2 | (2S,3S)-3-phenylpirrolidine-2-carboxylic acid |
7 − D | Ac-hrxyiah-NH2 | (2R,3R)-3-phenylpirrolidine-2-carboxylic acid |
8D | Ac-hrxyiah-NH2 | D-pipecolic acid |
9D | Ac-xrpyiah-NH2 | 4-thiazoyl-D-alanine |
