Figure 5

Effect of vancomycin-induced gut microbiota alteration on gastrointestinal morphology and physiology in germ-free (GF) mice. Change in (a) body weight and (b) food-intake in GF mice subjected to fecal transplantation (FT) using samples from vancomycin-treated mice (FT-V) or from control mice (FT-C). (c) Gastrointestinal transit time in GF mice with FT-V or FT-C. (d) Representative appearance of the cecum in GF mice with FT-V or FT-C. Length of (e) small intestine and (f) colon. (g) Weight of cecum. Results are expressed as the mean ± SE (n = 4 in each group). Significantly greater than GF mice with FT-C at the same time point: *P < 0.05. NS, not significant.