Figure 5 | Scientific Reports

Figure 5

From: Estrogen deficiency impairs integrin αvβ3-mediated mechanosensation by osteocytes and alters osteoclastogenic paracrine signalling

Figure 5

The effect of αvβ3 antagonism and oscillatory fluid flow on MLO-Y4 cell morphology. (A) Immunocytochemistry images showing actin fibres and vinculin staining (N = 3, n ≥ 90 cells per group). Quantification of the images showing (B) cell area, (C) % focal adhesion area/cell area, (D) actin fluorescent intensity, and (E) anisotropy of actin fibres. (Student’s t-test, ##p < 0.01 compared to static, ###p < 0.001 compared to static, ####p < 0.0001 compared to static, $$$$p < 0.0001 compared to flow).

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