Figure 2

Medication–Lyme disease comorbidity network, analyzed by CCS-single-level categories, in time windows of 5 years (A) and 10 years (B). Significant associations between medications (cyan) and comorbidities (magenta) are connected by red or blue lines (p < 0.1). Red lines indicate risk associations (OR > 1), and blue lines indicate protective associations (OR < 1). Medications and indications (green) were connected based on information in the public knowledgebase MEDI44.