Table 2 Diseases associated with Lyme, by ICD-9 code. A total of 3,639 diseases were tested.

From: Lyme Disease Patient Trajectories Learned from Electronic Medical Data for Stratification of Disease Risk and Therapeutic Response

Time (year)

Direction

Disease (CCS)

ICD9

Disease (ICD9)

Lyme First

Disease First

Same Time

p value (binomial)

Prob. (binomial)

p value (logistic regression)

OR (logistic regression)

5

—

HIV infection

V08

HIV positive NOS

0

21

8

1.21E-02

0.72

1.80E-05

2.17

5

—

Administrative/social admission

V20.2

Routin child health exam

16

49

4

3.18E-04

0.71

1.31E-02

2.08

5

+

Nutritional deficiencies

268.9

Vitamin D deficiency NOS

203

124

36

1.37E-02

0.56

1.20E-177

5.64

5

+

Cataract

366.9

Cataract NOS

40

18

7

4.08E-02

0.62

2.90E-30

4.27

5

+

Acute bronchitis

466.0

Acute bronchitis

36

16

3

1.50E-02

0.65

4.02E-21

3.56

5

+

Nonmalignant breast conditions

793.80

Unspecified abnormal mammogram

28

12

0

8.29E-03

0.70

8.92E-10

2.61

10

—

HIV infection

V08

HIV positive NOS

0

24

8

3.50E-03

0.75

1.80E-05

2.17

10

—

Disorders of lipid metabolism

272.0

Pure hypercholesterolem

84

159

50

8.04E-02

0.54

1.60E-30

2.22

10

—

Disorders of lipid metabolism

272.4

Hyperlipidemia NEC/NOS

97

187

64

9.01E-02

0.54

1.06E-18

1.78

10

—

Essential hypertension

401.9

Hypertension NOS

96

247

120

8.16E-02

0.53

9.83E-08

1.39

10

—

Administrative/social admission

V20.2

Routin child health exam

17

54

4

8.82E-05

0.72

1.31E-02

2.08

10

+

Nutritional deficiencies

268.9

Vitamin D deficiency NOS

211

124

36

4.67E-03

0.57

1.20E-177

5.64

10

+

Cataract

366.16

Senile nuclear cataract

17

2

1

1.29E-03

0.85

2.94E-03

1.97

10

+

Cataract

366.9

Cataract NOS

45

21

7

3.02E-02

0.62

2.90E-30

4.27

10

+

Inflammation; infection of eye (except that caused by tuberculosis or sexually transmitted disease)

373.00

Blepharitis NOS

33

2

1

1.14E-07

0.92

2.27E-14

3.79

10

+

Other eye disorders

375.15

Tear film insuffic NOS

24

11

1

3.26E-02

0.67

4.44E-12

3.36

10

+

Acute bronchitis

466.0

Acute bronchitis

37

17

3

1.66E-02

0.65

4.02E-21

3.56

10

+

Nonmalignant breast conditions

793.80

Unspecified abnormal mammogram

31

12

0

2.70E-03

0.72

8.92E-10

2.61

  1. This table includes only the ICD-9 diseases that are classified into the CCS-single-level categories shown in (a), and a full list of associations is provided in Supplementary Table 1.