Figure 1
DNA origami reporter design. (a) DNA origami folding steps with the first step to fold the triangular structure with probe strands to capture the target and handles for dye labeled DNA. In the subsequent hybridisation step, the dye labeled DNAs are positioned on the predetermined locations on the DNA origami. (b) DNA origami reporter design with 14 dye molecules (red circles) placed with approximately 11 nm gap on one trapezoid and four probe strands (purple lines) on a different trapezoid of the triangular DNA origami nanostructure. (c) AFM image of the folded triangular DNA origami nanostructures (scale bar 100 nm) with a height profile of approximately 1.8 nm.
