Figure 3 | Scientific Reports

Figure 3

From: Non-canonical WNT-signaling controls differentiation of lymphatics and extension lymphangiogenesis via RAC and JNK signaling

Figure 3

Whole-mount immunostaining of dermal lymphatics of ED 18.5 mouse embryos. Staining with anti-CD31 (green) and anti-Lyve-1 (red) antibodies. Lymphatics (yellow; arrows) are double positive. Note regular, slender lymphatic networks in wt-embryos and Wnt5a+/− -embryos, and cyst-like lymphatics in Wnt5a-null embryos. Blood capillaries (green) are less frequent in Wnt5a-null embryos. Numerous Lyve-1-positive scattered cells are visible (red). Bar = 40 µm.

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