Figure 5 | Scientific Reports

Figure 5

From: Andrographolide attenuates imbalance of gastric vascular homeostasis induced by ethanol through glycolysis pathway

Figure 5

Andrographolide suppresses endothelial PFKFB3 mediated glycolysis pathway. (A) Quantitative real time RT-PCR analysis of the expression of glycolysis related genes in HUVEC-C following andrographolide treatment. (B) Western blot analysis PFKFB3 expression in HUVEC-C after andrographolide treatment and the quantification data displayed in (C). All data presented as mean ± SEM, *P < 0.05 was considered significant. The experiments repeated three times. (D) IHC was performed to observe the expression of PFKFB3 in gastric wall. (E,F) HUVEC treated with 3-PO, a PFKFB3 inhibitor, would scratch and cell number accounting experiment performed to detect the proliferation and migration.

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