Figure 6
Andrographolide inhibits gastric inflammation. (A) Representative Immunohistochemistry staining against Mac-2 on sections of gastric ulcer from mice pretreated with vehicle or andrographolide. The number of Mac-2 quantified in (B). Data were presented as mean ± SEM (n = 10, *P < 0.05). (C) Quantitative real time RT-PCR analysis of inflammatory response genes in HUVEC-C pretreated with andrographolide (5 μM/ml) for 24 hours. Data presented as mean ± SEM. Experiments repeated twice. *P < 0.05. (D) Schematic diagram demonstrates the function role of andrographolide in attenuating imbalance of vascular homeostasis in a gastric ulcer animal model induced by ethanol intragastric administration through endothelial glycolytic pathway.
