Figure 5
From: Nanoscale structure of amyloid-β plaques in Alzheimer’s disease
Non-fibrillar Aβ structures are increased in an ADAD case. (A–F) Representative images of non-fibrillar Aβ structures distribution and size identified in plaques of an ADAD (n = 8) and a SAD (n = 5) case using AT-STED. Neurofilament light protein (magenta) was stained to visualize the neuronal distribution around the plaques. Scale bar = 10 µm and 1 µm for the inset. (G) ADAD and SAD distribution of NAB61 structures number by size. Differences were found between both distributions (p < 0.001). (H) All Aβ entities were significantly increased in ADAD compared to SAD case (p < 0.001).
