Table 2 Outcomes of controlled ovarian stimulation, fertilization, and embryo transfer.

From: Progesterone elevation on the day of hCG trigger has detrimental effect on live birth rate in low and intermediate ovarian responders, but not in high responders

Variable

Low responders (n = 358)

Intermediate responders (n = 1,649)

High responders (n = 344)

p value

Duration of stimulation (d)

8.89 ± 1.92

9.05 ± 1.95

9.20 ± 1.77

<0.01c

Total dose of Gn (IU)

1929.52 ± 746.47

1795.21 ± 678.77

1682.63 ± 669.46

<0.01a,b,c

Endometrial thickness on hCG day(mm)

11.08 ± 2.1

11.33 ± 2.1

11.35 ± 2.0

NS

LH level on hCG day (IU/L)

4.73 ± 3.98

4.10 ± 3.32

3.53 ± 2.83

<0.05a,b,c

E2 level on hCG day (pg/mL)

2168.01 ± 1561.77

3873.55 ± 2118.79

6095.13 ± 2587.22

<0.01a,b,c

P level on hCG day (ng/mL)

1.03 ± 1.48

1.17 ± 1.10

1.47 ± 1.26

<0.01a,b,c

No. of oocytes retrieved

3.77 ± 1.20

11.40 ± 3.57

22.90 ± 4.23

<0.01a,b,c

No. of 2PN oocytes

2.53 ± 1.17

6.94 ± 3.38

14.27 ± 4.87

<0.01a,b,c

2PN rate (%)

907/1009 (89.89)

11440/13160 (86.93)

4909/5771 (85.06)

<0.01a,b,c

No. of good-quality embryos

1.31 ± 1.09

3.54 ± 2.58

7.12 ± 4.03

<0.01a,b,c

Good-quality embryos rate (%)

468/795 (58.87)

5836/9701 (60.16)

2450/4137 (59.22)

NS

No. of embryos transferred

1.72 ± 0.54

2.05 ± 0.38

2.06 ± 0.28

<0.01a,c

At least one good-quality embryo transferred rate (%)

266/358 (74.30)

1512/1649 (91.69)

331/344 (96.22)

<0.01a,b,c

No. of embryos frozen

1.65 ± 0.61

3.92 ± 2.35

7.56 ± 4.4

<0.01a,b,c

Clinical pregnancy rate (%)

80/358 (22.35)

533/1649 (32.32)

96/344 (27.91)

<0.01a

Implantation rate (%)

94/617 (15.24)

636/3378 (18.83)

110/707 (15.56)

<0.05a,b

Live birth rate (%)

59/358 (16.48)

398/1649 (24.15)

69/344 (20.05)

<0.01a

  1. E2, estradiol; Gn, gonadotropin; hCG, human chorionic gonadotropin; LH, luteinizing hormone; NS, not significant.
  2. Values are presented as the means ± standard deviations or counts (%). ANOVA or chi-square test.
  3. aSignificant difference between low and intermediate ovarian responders.
  4. bSignificant difference between intermediate and high ovarian responders.
  5. cSignificant difference between low and high ovarian responders.