Table 2 Summary of the observations made on the influence of demographical factors.
Demographical considerations | Group | N | In accordance with previous works |
---|---|---|---|
NcirDNA concentration | |||
A statistical difference between males and females | Healthy | 104 | Catarino R, et al.63 |
No statistical difference between males and females | mCRC | 118 | Hao TB, et al.31 |
A statistical difference with regard to age | Healthy | 104 | Jylhävä J, et al.35 |
No statistical difference with regard to age | mCRC | 118 | Van der Drift MA, et al.30 |
Statistical increase in mCRC patients as compared to healthy individuals | Healthy mCRC | 104 118 | Bedin C, et al.64 |
McirDNA concentration | |||
No statistical difference between males and females | Healthy mCRC | 104 50 | New observation |
No statistical difference with regard to age | Healthy mCRC | 104 50 | Jylhävä J, et al.35 New observation |
Statistical decrease in mCRC patients as compared to healthy individuals | Healthy mCRC | 104 50 | New observation |
McirDNA vs NcirDNA concentration | |||
Necessity of independently quantifying NcirDNA and McirDNA | |||
About 50,000-fold more McirDNA copy number as compared to NcirDNA in healthy individuals | Healthy | 104 | New observation |
About 3,000-fold more McirDNA copy number as compared to NcirDNA in cancer patients | mCRC | 50 | New observation |
About 20-fold more McirDNA/NcirDNA ratio in healthy individuals as compared to mCRC patients | Healthy mCRC | 104 50 | New observation |