Table 2 Summary of the observations made on the influence of demographical factors.

From: Quantifying circulating cell-free DNA in humans

Demographical considerations

Group

N

In accordance with previous works

NcirDNA concentration

A statistical difference between males and females

Healthy

104

Catarino R, et al.63

No statistical difference between males and females

mCRC

118

Hao TB, et al.31

A statistical difference with regard to age

Healthy

104

Jylhävä J, et al.35

No statistical difference with regard to age

mCRC

118

Van der Drift MA, et al.30

Statistical increase in mCRC patients as compared to healthy individuals

Healthy

mCRC

104

118

Bedin C, et al.64

McirDNA concentration

No statistical difference between males and females

Healthy

mCRC

104

50

New observation

No statistical difference with regard to age

Healthy

mCRC

104

50

Jylhävä J, et al.35

New observation

Statistical decrease in mCRC patients as compared to healthy individuals

Healthy

mCRC

104

50

New observation

McirDNA vs NcirDNA concentration

Necessity of independently quantifying NcirDNA and McirDNA

About 50,000-fold more McirDNA copy number as compared to NcirDNA in healthy individuals

Healthy

104

New observation

About 3,000-fold more McirDNA copy number as compared to NcirDNA in cancer patients

mCRC

50

New observation

About 20-fold more McirDNA/NcirDNA ratio in healthy individuals as compared to mCRC patients

Healthy

mCRC

104

50

New observation