Figure 2

Serum Levels of PSP/reg in Human subjects with Wolfram Syndrome. PSP/reg levels were obtained from all available subjects attending the 2014 Wolfram syndrome research clinic. This included 28 subjects with Wolfram syndrome, and 28 control subjects (parents or siblings of subjects with Wolfram syndrome). The mean PSP/reg level in the Wolfram group was 23.1 ng/mL (SD 29.9), compared to 15.1 ng/mL (SD 10.2) in the control group. The median PSP/reg level in the Wolfram group was 12.2 ng/mL (interquartile range 10.4–18.1 ng/mL), compared to 12.9 ng/mL (interquartile range 10.6–17.7 ng/mL). Despite the similarities between the Wolfram and control groups, we noted that 3 subjects with Wolfram syndrome had relatively elevated levels of PSP/reg (WU-WOLF-03, WU-WOLF-11, WU-WOLF-12). From the control group one subject (WU-WOLF-03 (Mother)), also had relatively elevated levels of PSP/reg.