Table 2 Phenotype measures by PER2 rs35333999 genotype and results from association testing for in-laboratory participants of European ancestry.
From: Chronotype Genetic Variant in PER2 is Associated with Intrinsic Circadian Period in Humans
Phenotype | n | Mean (SD) | n | Mean T Carriers | n | Mean Non-T Carriers | Beta (SE) | p |
|---|---|---|---|---|---|---|---|---|
Age (years) | 196 | 26.93 (11.16) | 13 | 26.15 (5.11) | 183 | 26.99 (11.48) | — | — |
Sex (M/F) | 196 | 126/70 | 13 | 8/5 | 183 | 118/65 | — | — |
MEQ score* | 193 | 52.29 (12.14) | 12 | 47.17 (15.27) | 181 | 52.63 (11.88) | −3.87 (3.08) | 0.210 |
CBT period (h) | 63 | 24.16 (0.20) | 6 | 24.34 (0.17) | 57 | 24.14 (0.20) | 0.20 (0.09) | 0.030 |
MEL period (h) | 57 | 24.17 (0.19) | 5 | 24.34 (0.18) | 52 | 24.15 (0.19) | 0.19 (0.09) | 0.039 |
CBT phase (clock h) | 90 | 5:00 (2:07) | 6 | 4:53 (1:58) | 84 | 5:01 (2:08) | 0.19 (0.91) | 0.836 |
MEL phase (clock h) | 102 | 22:25 (1:52) | 5 | 22:49 (1:32) | 97 | 22:24 (1:53) | 0.67 (0.82) | 0.415 |
CBT phase angle (h) | 88 | −3.19 (1.33) | 6 | −2.88 (1.08) | 82 | −3.22 (1.35) | 0.55 (0.60) | 0.360 |
MEL phase angle (h) | 100 | −9.49 (1.21) | 5 | −9.06 (1.10) | 95 | −9.51 (1.21) | 0.57 (0.57) | 0.304 |
Bedtime (clock h) | 152 | 23:57 (1:27) | 9 | 0:17 (1:44) | 143 | 23:56 (1:26) | 0.47 (0.47) | 0.315 |
Wake time (clock h) | 152 | 7:59 (1:27) | 9 | 8:17 (1:41) | 143 | 7:58 (1:26) | 0.42 (0.47) | 0.380 |
TIB duration (h) | 152 | 8.04 (0.13) | 9 | 7.99 (0.16) | 143 | 8.05 (0.13) | −0.06 (0.05) | 0.222 |
TIB midpoint (clock h) | 152 | 3:58 (1:27) | 9 | 4:17 (1:43) | 143 | 3:57 (1:26) | 0.44 (0.47) | 0.346 |
