Figure 2 | Scientific Reports

Figure 2

From: Histone deacetylase inhibitors restore normal hippocampal synaptic plasticity and seizure threshold in a mouse model of Tuberous Sclerosis Complex

Figure 2

HDAC inhibition restores WT-like STP in response to 1 × TBS in adult TSC2+/− mice. A 1 × TBS elicits STP in adult WT hippocampal slices (shown in blue; n = 11 slices from 5 mice), while it provokes long lasting LTP in adult TSC2+/− mice (shown in red; n = 9 slices from 5 mice; two-way ANOVA: F(1,17) = 10.45, p = 0.0049). TSC2+/− slices incubated in TSA (1.65 µM) exhibited STP that was indistinguishable from untreated WT slices (n = 7 slices from 5 mice; two-way ANOVA: F(1,15) = 0.0007718, p = 0.9782). WT slices treated with TSA display long lasting LTP similar to that seen in TSC2+/− hippocampal slices (shown in purple; n = 6 slices from 6 mice; two-way ANOVA: F(1.13) = 1.557, p = 0.2350). TSA was introduced to the slices 60 minutes prior to 1 × TBS and was kept on for the duration of the experiment.

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