Figure 1
From: Computer aided protein engineering to enhance the thermo-stability of CXCR1- T4 lysozyme complex
CXCR1 protein and structural templates. (a) Topology and primary structure of CXCR1, with the residues subject to mutation colored in green. The snake plot was drawn with GPCRdb17. (b) The structure comparison of two homology template structures: CCR2-T4L (PDB ID: 5T1A, colored in yellow) and the CXCR4-T4L (PDB ID: 4RWS, colored in brown). The black arrow points to the TM5, where the helix conformation extends to the T4L domain in the case of CXCR4-T4L. (c) The structure comparison of CCR2-T4L and CXCR4-T4L at the extracellular domain reveals the CXCR4-T4L binding pocket for ligand (vMIP-II, not shown) is in the open conformation.
