Figure 1 | Scientific Reports

Figure 1

From: Synthetic standard aided quantification and structural characterization of amyloid-beta glycopeptides enriched from cerebrospinal fluid of Alzheimer’s disease patients

Figure 1

Reagents and conditions: (a) NaHCO3, H2O; (b) Ac2O, pyridine, DMAP, 0 °C to rt; (c) p-toluenethiol, DCM, BF3.Et2O, rt; (d) Zn, MeOH:AcOH:DCM (2:1:1); (e) NaOMe/MeOH; (f) triflic azide, K2CO3, CuSO4, H2O/toluene/MeOH, rt; (g) benzaldehyde dimethylacetal, p-toluenesulfonic acid, acetonitrile; (h) molecular sieves (MS) 4 Å, AgOTf, p-TolSCl, 9, TTBP, −78 °C, DCM; (i) aq. AcOH (80%), 80 °C; (j) 4 Å MS, AgOTf, p-TolSCl, TTBP, −78 °C, DCM; (k) TFA/ H2O (9/1).

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