Figure 5

Animal species used in this study, their evolutionary relationship and muscular expression pattern of creatine-related genes. Data for the separation of species was taken from the TimeTree of Life project (http://www.timetree.org/). Squares show the strength of the expression of each gene. Blue squares indicate highest expression in the muscle in comparison to the liver and kidneys, white squares an intermediate expression between the other tissues and red ones the lowest expression. Rotation of the square indicates if data was gained from RNA-Seq or qRT-PCR. Animal names and taxonomy are based on the NCBI Taxonomy browser (www.ncbi.nlm.nih.gov/Taxonomy) and NCBI LinkOut pages, such as the Animal Diversity Web of the Museum of Zoology at the University of Michigan (www.animaldiversity.org). Human and animal art illustrations were kindly contributed by Luisa Falkenthal.