Figure 4 | Scientific Reports

Figure 4

From: The Role of AMPARs in the Maturation and Integration of Caudal Ganglionic Eminence-Derived Interneurons into Developing Hippocampal Microcircuits

Figure 4

GluA1-3 KO CGE interneurons have more extensive dendritic arbours. (A) Representative samples of reconstructed WT or GluA1-3 KO CGE basket, Wide arbour dendrite targeting, and Schaffer collateral associated cells in CA1 hippocampus. Dendrites (black) and axons (red) were defined based on the fluorescent signal and the apparent differences in their thickness. Dendrites of all three morphological subgroup extend to stratum oriens, stratum pyramidale, stratum radiatum and sometimes stratum lacunosum-moleculare layers of CA1. Dashed lines demarcate the borders of these layers. (B) Line graphs for dendritic branching depicted as number of intersections on concentric circles (20 μm intervals) from the cell soma by Scholl analysis. (C) Bar graphs for the total dendritic length indicate that only basket cells increased their overall dendritic length. Significance tested with ANOVA and a posthoc Tukey Test. *p < 0.05.

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