Figure 9

FG-4592 upregulated the expression of HIF-1α and VEGF in vivo. Fibrovascular tissue at the matrix-host interface was selected as the region of interest (ROI). Red stained HIF-1α (+) cells and diffused brown stained VEGF (+) cells were observed in all groups (A). In drug administered group (LD and HD), the numbers of HIF-1α (+) as well as VEGF (+) cell were higher than in negative control (B,C). Scale bar: black = 100 um, blue = 25 um.