Figure 6

Hypothesis: the role of autophagy in nPt metabolism in trophoblast cells. When nPt intrude into trophoblast cells, they are initially captured by autophagosomes. However, excessive nPt that escape from autophagosomes may accumulate in nuclei and damage DNA, resulting in cell death. On the other hand, nPt easily accumulate in nuclei in autophagy-deficient cells because of the lack of autophagosomes. As a result, autophagy-deficient cells may be sensitive to the cytotoxicity of nPt.