Figure 1 | Scientific Reports

Figure 1

From: Metabolic resistance of the D-peptide RD2 developed for direct elimination of amyloid-β oligomers

Figure 1

Schematic overview of the methodological approaches. It was investigated whether the D-peptide RD2 is a substrate or inhibitor for enzymes contained in simulated gastric and intestinal fluid, human blood plasma and human liver microsomes or for the D-amino acid oxidase. RD2’s mirror image l-RD2 served as comparative substance. Potential human-specific metabolites generated in liver microsomes were identified and characterized.

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