Figure 5
From: Metabolic resistance of the D-peptide RD2 developed for direct elimination of amyloid-β oligomers
Metabolite profiles of RD2 incubated in human, rat and cynomolgus liver microsomes showing non-human-specific metabolites. RD2 was incubated in human, rat and cynomolgus liver microsomes for 0 and 24 h and chromatograms were recorded to search for potential human-specific metabolites. Incubated liver microsomes without RD2 served as controls. Only the relevant parts of the chromatogram are shown. Left: section of the chromatogram including the RD2 peak. Right: amplified section of the y-axis to focus on small metabolite peaks. In the human samples, only one metabolite with a peak area of less than 2% in comparison to the parent compound peak area appeared (A). This metabolite (see arrows) was also present in rat (B) and cynomolgus (C) samples.
