Figure 6
From: Metabolic resistance of the D-peptide RD2 developed for direct elimination of amyloid-β oligomers
Metabolite profiles of RD2 incubated in human liver microsomes showing potential human-specific metabolites. RD2 was incubated in human, rat and cynomolgus liver microsomes for 0 and 24 h and chromatograms were recorded. Incubated liver microsomes without RD2 served as controls. Only the relevant parts of the chromatograms from the human samples are shown. Two minor potentially human-specific metabolites (HSM-1 & HSM-2) appeared in batch no. 5, which represented 3 to 5% of the parent compound (A). One major potentially human-specific metabolite (HSM-3), only detected in the human samples 7 & 8, represented 31 or 52% of the parent compound (B).
