Table 10 Haematological and clinical chemistry parameters with significant differences compared to the control animals. Differences are not considered to be test item-related.

From: Toxicological testing of allogeneic secretome derived from peripheral mononuclear cells (APOSEC): a novel cell-free therapeutic agent in skin disease

Parameter

mean value SD

Group/Sex

Test day(s)

Statistical significance

Reason

Haemoglobin (mmol/L)

9.32

0.19

4 m

−5

p ≤ 0.05

C

Leucocytes (×103/µL)

11.753

1.720

3 m

30

p ≤ 0.05

A

13.946

2.708

4 m

30

p ≤ 0.05

A

Haematocrit (%)

46.0,3

2.14

2 m

−5

p ≤ 0.05

C

45.72

0.76

4 m

−5

p ≤ 0.05

C

Eosinophilic

granulocytes (×103/µL

0.317

0.072

2 m

−5

p ≤ 0.05

C

0.303

0.065

3 m

−5

p ≤ 0.05

C

0.273

0.075

2 m

30

p ≤ 0.01

A

0.327

0.176

3 m

30

p ≤ 0.01

A

0.506

0.143

4 m

30

p ≤ 0.01

A

Basophilic

granulocytes

0.050

0.010

3 m

30

p ≤ 0.05

A, B

Beta-Globulin

12.97

0.12

2 m

30

p ≤ 0.05

A, B

ASAT

54.0

26.9

2 m

30

p ≤ 0.01

A, B

LDH

674.0

112.7

2 m

30

p ≤ 0.01

A, B

CK

1799.7

1789.6

2 m

30

p ≤ 0.05

A, B

GLDH

3.63

2.70

3 f

−5

p ≤ 0.01

C

  1. m: male.
  2. f: female.
  3. A: the slight alteration in comparison to control animals is without any biological relevance.
  4. B: lacking dose dependence.
  5. C: effect observed before start of treatment.
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