Table 3 Concentration of APOSEC in the minipig s.c. study.

From: Toxicological testing of allogeneic secretome derived from peripheral mononuclear cells (APOSEC): a novel cell-free therapeutic agent in skin disease

Dose level

[U/kg b.w.]

Content per test item vial

[U]

Concentration [U/mL]

Administration volume

[mL/animal]

Administration volume

[mL/kg b.w.]

3.3

500

25

1.98

0.132

10.5

500

25

6.30

0.420

33.3

500

25

19.80

1.332

  1. D1: 3.3 U/kg; max 15 kg = 49.5 Mio/animal = 1.98 mL.
  2. D2: 10.5 U/kg; max 15 kg = 157.5 Mio/animal = 6.30 mL.
  3. D3: 33.3 U/kg; max 15 kg = 495.0 Mio/animal = 19.80 mL.
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