Table 5 Results of LLNA of APOSEC in mice.

From: Toxicological testing of allogeneic secretome derived from peripheral mononuclear cells (APOSEC): a novel cell-free therapeutic agent in skin disease

Parameter

Group 1 Negative control

Group 2

25 U/kg b.w.

Group 3

125 U/kg b.w.

Group 4

250 U/kg b.w.

Group 5 Positive control

Group 6

Vehicle of positive control

BrdU labelling

1.000

1.216

1.175

1.279*

1.831*

1.419*

Ear weight

1.000

0.965

0.913

0.913

1.070*

0.890

Difference in ear thickness (day 3)

1.000

0.976

1.010

1.005*

1.208*

1.020

Difference in ear thickness (day 6)

1.000

0.995

1.010

1.005*

1.130*

1.058*

  1. *Significant increase compared to control at p ≤ 0.01.
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