Table 8 Assessment of local intolerance reactions according to DRAIZE.
Macroscopic changes at the injection sites of the main study animals at terminal sacrifice on test day 30 (animals affected/animals examined) | ||||||||
|---|---|---|---|---|---|---|---|---|
Finding | Group 1 Control | Group 2 3.3 U/kg | Group 3 10.5 U/kg | Group 4 33.3 U/kg | ||||
m | f | m | f | m | f | m | f | |
Haemorrhage, s.c. | 0/3 | 0/3 | 0/3 | 2/3 | 1/3 | 1/3 | 1/3 | 1/3 |
Thickened | 0/3 | 0/3 | 0/3 | 0/3 | 0/3 | 1/3 | 0/3 | 0/3 |
