Table 9 Local intolerance in form of reddenings, swellings and/or thickenings of the subcutaneous injection sites.

From: Toxicological testing of allogeneic secretome derived from peripheral mononuclear cells (APOSEC): a novel cell-free therapeutic agent in skin disease

Local intolerance reactions during the treatment period

(animals affected/animals examined)

Finding/Incidence

Group 1

Control

Group 2

3.3 U/kg

Group 3

10.5 U/kg

Group 4

33.3 U/kg

m

f

m

f

m

f

m

f

Discoloured, reddened

or thickened

0/5

0/5

0/3

1/3

1/3

2/3

0/5

1/5

noted on up to

‘x’ test days

—

—

—

1

6

2

—

1

  1. m: male.
  2. f: female.
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