Figure 1
From: Fetal lung C4BPA induces p100 processing in human placenta
Proteomics analysis of fetal cord blood exosomes. (A) Isolation procedure of fetal cord blood exosomes. (B) The heatmap showing select proteins with significant difference in normalized abundance in fetal exosomes among groups as indicated (*p < 0.01). PCS-A, arterial blood exosomes isolated from patients of 35 to 36 weeks of EGA following C-section; TCS-A, arterial blood exosomes isolated from patients of 39 to 40 weeks of EGA following C-section; TCS-V, vein blood exosomes isolated from the same patients of 39 to 40 weeks of EGA following C-section; TSL-A, arterial blood exosomes isolated from patients of 39 to 40 weeks of EGA following spontaneous labor and vaginal delivery. The complete proteomics data is shown in Supplementary Table 1. (C) Venn diagram showing the number of exosomal proteins identified in this study, which were overlapped with those published to date11. Red circle indicates top 100 exosomal protein markers. (D) Imaging of exosomes isolated from the cord arterial blood of the groups as indicated by transmission electron microscope (left panels). For each group, the percentage of microvesicles based on the sizes as indicated was calculated from 10 random fields (right panels). Original magnification, X 45,000.
