Figure 10
From: Evolution of folate biosynthesis and metabolism across algae and land plant lineages
Sources of one-carbon units in the plant cell. Arrows in bold indicate sources of one-carbon units. THF, tetrahydrofolate; 5-CH3-THF, 5-methyltetrahydrofolate; 5,10-CH2-THF, 5,10-methylenetetrahydrofolate; 5,10-CH+-THF, 5,10-methenyltetrahydrofolate; 5-CHO-THF, 5-formyltetrahydrofolate; 10-CHO-THF, 10-formyltetrahydrofolate; Ser, serine; Gly, glycine. SHMT, serine hydroxymethyltransferase; GDC, glycine decarboxylase complex, FTHFC, formiminotetrahydrofolate cyclodeaminase; 5-FCL, 5-formyltetrahydrofolate cycloligase; GFT, glutamate formiminotransferase; FTHFS, 10-CHO-THF synthetase; MTHFD-MTHFC, 5,10- CH2-THF dehydrogenase/5,10-CH+-THF cyclohydrolase; MTHFR, methylenetetrahydrofolate reductase; 10-FDF, 10-CHO-THF deformylase.
