Figure 5

Tubular dysfunction: panel a) alteration of PTEC polarity induced by TBI plasma incubation for 12 hrs. Comparison between TBI and control groups was made by test U Mann-Whitney, unpaired (*p = 0.003). Panel b) qRT-PCR analysis of Megalin transcript levels in PTEC. Results were normalized to GAPDH expression. Comparison between TBI (n = 23) and control (n = 4) groups was made by test U Mann-Whitney, unpaired (*p = 0.008; data are presented as box plot with median and IQ1-IQ3).