Table 1 List of metabolic pathways in Vibrio sp. that were significantly affected by ITA exposure.

From: Itaconic acid inhibits growth of a pathogenic marine Vibrio strain: A metabolomics approach

Pathways

Hits/Total compounds

Raw p

FDR

Impact

Alanine, aspartate and glutamate metabolism

6/18

<0.001

<0.001

0.479

Glycine, serine and threonine metabolism

6/32

0.001

0.001

0.473

Pyruvate metabolism

3/26

0.005

0.007

0.438

Glutathione metabolism

5/21

<0.001

<0.001

0.381

Citrate cycle (TCA cycle)

8/20

<0.001

<0.001

0.301

Butanoate metabolism

4/18

<0.001

0.001

0.255

Cysteine and methionine metabolism

6/34

0.001

0.001

0.230

Arginine and proline metabolism

8/41

<0.001

0.001

0.215

Glycolysis or Gluconeogenesis

2/29

0.192

0.192

0.168

Methane metabolism

2/11

<0.001

<0.001

0.167

Aminoacyl-tRNA biosynthesis

18/66

<0.001

<0.001

0.130

Glyoxylate and dicarboxylate metabolism

5/29

<0.001

<0.001

0.102

Nicotinate and nicotinamide metabolism

2/13

0.001

0.001

0.089

Sulfur metabolism

2/13

0.001

0.001

0.069

Valine, leucine and isoleucine biosynthesis

5/26

<0.001

<0.001

0.036

C5-Branched dibasic acid metabolism

2/6

<0.001

<0.001

0.000

Benzoate degradation via CoA ligation

3/10

<0.001

<0.001

0.000

Valine, leucine and isoleucine degradation

3/23

<0.001

<0.001

0.000

beta-Alanine metabolism

2/16

<0.001

0.001

0.000

Nitrogen metabolism

5/18

<0.001

0.001

0.000

Phenylalanine, tyrosine and tryptophan biosynthesis

4/23

<0.001

0.001

0.000

Thiamine metabolism

2/19

<0.001

0.001

0.000

Lysine biosynthesis

2/13

<0.001

0.001

0.000

Cyanoamino acid metabolism

4/8

0.001

0.001

0.000

Phenylalanine metabolism

4/23

0.001

0.001

0.000

Pantothenate and CoA biosynthesis

4/23

0.001

0.001

0.000

Tyrosine metabolism

2/10

0.002

0.003

0.000

Biosynthesis of unsaturated fatty acids

3/6

0.011

0.015

0.000

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